Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, US

Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in Texas, US

Highly pathogenic avian influenza viruses (HPAIV) pose serious public health concerns. In March 2024, a first-time outbreak of HPAIV H5N1 in dairy cattle herds was reported in the United States (US). Since then, the virus has continued to spread in cattle herds and spilt over into humans. We recentl...

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Bibliographic Details
Main Authors: Mahmoud Bayoumi, Ramya S. Barre, Ruby A. Escobedo, Vinay Shivanna, Nathanial Jackson, Chengjin Ye, Adolfo García-Sastre, Ahmed Mostafa, Luis Martinez-Sobrido
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Avian influenza
HPAIV
H5N1
minigenome assay
PB2
spillover
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2542247
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