MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis

MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis

Abstract Various signaling pathways are essential for both the innate immune response and the maintenance of cell homeostasis, requiring coordinated interactions among them. In this study, a mutation in the caspase-1 recognition site within MyD88 abolished inflammasome-dependent negative regulation,...

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Bibliographic Details
Main Authors: Duško Lainšček, Simon Horvat, Klemen Dolinar, Filip Ivanovski, Rok Romih, Sergej Pirkmajer, Roman Jerala, Mateja Manček-Keber
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
MyD88
NF-κB signaling
Apoptosis
Homeostasis
Oxidative stress
Online Access:https://doi.org/10.1186/s12964-024-01930-1
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https://doi.org/10.1186/s12964-024-01930-1

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