HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells

HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells

Summary: Herpes simplex virus type 1 (HSV-1) significantly impairs dendritic cell (DC) function, ultimately eliciting the death of these cells. Here, we sought to assess whether HSV-1 modulates lipid metabolism in mouse DCs as a mechanism of immune evasion. For this, we performed RT-qPCR gene arrays...

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Main Authors: Mónica A. Farías, Felipe A. Cancino, Areli J. Navarro, Luisa F. Duarte, Abel A. Soto, Eduardo I. Tognarelli, Maximiliano J. Ramm, Bárbara N. Alarcón-Zapata, José Cordero, Sergio San Martín, Cristian Agurto-Muñoz, Angello Retamal-Díaz, Claudia A. Riedel, Nelson P. Barrera, Luis Bustamante, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Immunology
Microbiology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007023
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http://www.sciencedirect.com/science/article/pii/S2589004225007023

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