Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Abstract Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, including the complement component C5a, is associat...

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Main Authors: Mustafa Titiz, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Matilde Marini, Viola Seravalli, Martina Chieca, Pasquale Pensieri, Marco Montini, Gaetano De Siena, Benedetta Pasquini, Silvia Vannuccini, Luigi Francesco Iannone, Thiago M. Cunha, Giulia Brancolini, Elisa Bellantoni, Irene Scuffi, Alessandra Mastricci, Martina Tesi, Mariarosaria Di Tommaso, Felice Petraglia, Pierangelo Geppetti, Romina Nassini, Francesco De Logu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54486-6
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https://doi.org/10.1038/s41467-024-54486-6

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