The antipsychotic drug lurasidone inhibits coronaviruses by affecting multiple targets

The antipsychotic drug lurasidone inhibits coronaviruses by affecting multiple targets

Coronaviruses (CoVs) share key genomic elements critical for viral replication, suggesting the feasibility of developing therapeutics with efficacy across different viruses. In a previous work, we demonstrated the antiviral activity of the antipsychotic drug lurasidone against both SARS-CoV-2 and HC...

Full description

Saved in:
Bibliographic Details
Main Authors: Sara Baroni, Tea Carletti, Manuela Donalisio, Irene Arduino, Irene Cazzaniga, Toni Giorgino, Francesca Esposito, Alessia Porta, Luisa Diomede, Ada De Luigi, Marco Gobbi, David Lembo, Alessandro Marcello, Enzo Tramontano, Mario Milani, Eloise Mastrangelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
coronaviruses
papain-like protease
Spike protein
ACE2 interaction
dual-target compound
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1487604/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1487604/full

Similar Items