Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in <i>Plasmodium berghei</i>-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

Improved Malaria Therapy with Cationic Nanocapsules Demonstrated in <i>Plasmodium berghei</i>-Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling

<b>Objectives</b>: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in WB using <i>Plasmodiu...

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Main Authors: Tamara Ramos Maciel, Ana Claudia Funguetto-Ribeiro, Laura Ben Olivo, Flávia Elizabete Guerra Teixeira, Camila de Oliveira Pacheco, Bibiana Verlindo de Araujo, Sandra Elisa Haas
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceutics
Subjects:
interspecies translation
whole blood
quinine
nanocapsules
malaria
PK/PD modeling
Online Access:https://www.mdpi.com/1999-4923/16/11/1369
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