Pirfenidone reduces ovarian fibrosis and improves PCOS in letrozole-induced rat model

Pirfenidone reduces ovarian fibrosis and improves PCOS in letrozole-induced rat model

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by cystic ovarian morphology, anovulation, and infertility. Ovarian fibrosis has recently emerged as a key pathological feature of PCOS. This study investigated whether pirfenidone (PFD), an antifibrotic agent, could i...

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Bibliographic Details
Main Authors: Ayşe Çakır Gündoğdu, Neziha Senem Arı, Ahmet Koçak, Gülnihal Şenol, Asiye Höbel, Ömer Eldiven, Fatih Kar, Orhan Özatik
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2025-06-01
Series:Biomolecules & Biomedicine
Subjects:
Polycystic ovary syndrome
PCOS
ovarian fibrosis
pirfenidone
combined oral contraceptives
COC
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/12676
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