Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration

Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration

Abstract Brain metastasis (BM) remains a significant challenge in breast cancer (BC) management. While conventional metastatic routes primarily involve hematogenous dissemination, emerging evidence suggests that BC cells can also migrate along the abluminal surface of blood vessels, bypassing the bl...

Full description

Saved in:
Bibliographic Details
Main Authors: Haofeng Huang, Min Zhang, Enyu Huang, Yongfang Zhao, Xiaoyu Li, Pu Qiu, Cairui Li, Jiahua Tao, Yuanqi Zhang, Lianxiang Luo, Guozhu Ning, Ceshi Chen, Jingjing Zhang
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:EMBO Molecular Medicine
Subjects:
Breast Cancer
Brain Metastasis
Xenografted Model
LRP8
Reelin
Online Access:https://doi.org/10.1038/s44321-025-00260-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s44321-025-00260-0

Similar Items