Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus

Abstract Immunity and inflammation are implicated in the progression of keratoconus (KC), but the causal relationships between inflammatory immune phenotypes and the disease remain unclear. We conducted a comprehensive Mendelian randomization (MR) analysis using GWAS data to investigate the causal e...

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Bibliographic Details
Main Authors: Jialin Chen, Yanni Jia, Xiaolin Qi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-10759-8
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