嗜粘蛋白阿克曼氏菌通过调控CB<sub>2</sub>R缓解肠易激综合征大鼠内脏高敏

目的探讨嗜粘蛋白阿克曼氏菌在新生期母婴分离(MS)和避水应激(WAS)肠易激综合征(IBS)大鼠模型的内脏高敏发生中的作用。方法将SD雄性大鼠在新生期随机分为3组:sham WAS(空白组),MS+WAS组(IBS模型组)及阿克曼氏菌组(<italic>Akkermansia muciniphila, A. muciniphila</italic>组),IBS模型组及阿克曼氏菌组采用母婴分离联合避水应激方法(MS+WAS)建立内脏高敏感模型。母婴分离刺激结束后,阿克曼氏菌组每天避水应激处理同时灌胃1 mL 1×10<sup>9</sup> CFU...

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Bibliographic Details
Main Authors: 肖琳, 刘琴, 熊理守
Format: Article
Language:zho
Published: Editorial Office of Journal of Sun Yat-sen University 2023-05-01
Series:Zhongshan Daxue xuebao. Yixue kexue ban
Subjects:
Online Access:http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20230418.001/
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