The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst
This perspective critically examines the paradigm-shifting findings regarding cellular senescence’s dual role in tissue biology, particularly focusing on its unexpected regenerative potential in hair growth. While cellular senescence has traditionally been viewed as a detrimental process associated...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2025-01-01
|
| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0830 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849239957364801536 |
|---|---|
| author | Peng Li Yi Yang Xiang Qin Juan Liao |
| author_facet | Peng Li Yi Yang Xiang Qin Juan Liao |
| author_sort | Peng Li |
| collection | DOAJ |
| description | This perspective critically examines the paradigm-shifting findings regarding cellular senescence’s dual role in tissue biology, particularly focusing on its unexpected regenerative potential in hair growth. While cellular senescence has traditionally been viewed as a detrimental process associated with aging and tissue dysfunction, research has revealed its surprising beneficial effects on tissue regeneration. We analyze the groundbreaking discovery that senescent melanocytes can stimulate hair follicle stem cells through the osteopontin–CD44 signaling pathway, challenging the conventional understanding of senescence. This perspective also evaluates the implications of this finding for both basic research and therapeutic applications, suggesting that cellular senescence represents a complex, context-dependent phenomenon rather than a uniformly detrimental process. We discuss how this new perspective necessitates a more nuanced approach to senescence-targeted therapies and opens novel therapeutic possibilities for hair loss treatment. This analysis underscores the importance of understanding senescent cell heterogeneity and their diverse functions in tissue homeostasis, which could lead to more precise therapeutic strategies in regenerative medicine. |
| format | Article |
| id | doaj-art-9f76e895736e42aab815873e22f0b8bb |
| institution | Kabale University |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-9f76e895736e42aab815873e22f0b8bb2025-08-20T04:00:45ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0830The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative CatalystPeng Li0Yi Yang1Xiang Qin2Juan Liao3Department of Anesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.Department of Anesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.Department of Anesthesiology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.Department of Stomatology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.This perspective critically examines the paradigm-shifting findings regarding cellular senescence’s dual role in tissue biology, particularly focusing on its unexpected regenerative potential in hair growth. While cellular senescence has traditionally been viewed as a detrimental process associated with aging and tissue dysfunction, research has revealed its surprising beneficial effects on tissue regeneration. We analyze the groundbreaking discovery that senescent melanocytes can stimulate hair follicle stem cells through the osteopontin–CD44 signaling pathway, challenging the conventional understanding of senescence. This perspective also evaluates the implications of this finding for both basic research and therapeutic applications, suggesting that cellular senescence represents a complex, context-dependent phenomenon rather than a uniformly detrimental process. We discuss how this new perspective necessitates a more nuanced approach to senescence-targeted therapies and opens novel therapeutic possibilities for hair loss treatment. This analysis underscores the importance of understanding senescent cell heterogeneity and their diverse functions in tissue homeostasis, which could lead to more precise therapeutic strategies in regenerative medicine.https://spj.science.org/doi/10.34133/research.0830 |
| spellingShingle | Peng Li Yi Yang Xiang Qin Juan Liao The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst Research |
| title | The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst |
| title_full | The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst |
| title_fullStr | The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst |
| title_full_unstemmed | The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst |
| title_short | The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst |
| title_sort | dual nature of cellular senescence from aging signature to regenerative catalyst |
| url | https://spj.science.org/doi/10.34133/research.0830 |
| work_keys_str_mv | AT pengli thedualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT yiyang thedualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT xiangqin thedualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT juanliao thedualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT pengli dualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT yiyang dualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT xiangqin dualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst AT juanliao dualnatureofcellularsenescencefromagingsignaturetoregenerativecatalyst |