EGCG对人肝癌细胞株HepG2裸鼠移植瘤COX-2、VEGF和bFGF表达的调控
探讨表没食子儿茶素没食子酸脂EGCG对人肝癌细胞株HepG2裸鼠移植瘤生长和肿瘤血管生成的抑制作用及EGCG对移植瘤环氧合酶-2(COX-2)?血管内皮生长因子(VEGF)和碱性成纤维生长因子(bFGF)表达的调控?【方法】 将肝癌细胞HepG2种植至裸鼠背部皮下,10 d后开始用不同浓度EGCG治疗,38 d后处死?观测裸鼠移植瘤的体积和质量?并采用间接免疫流式细胞术和Western Blot法检测移植瘤COX-2?VEGF和bFGF的表达,用免疫组化法检测微血管密度(MVD)?【结果】 ①生理盐水组切除的移植瘤平均体积和质量分别是(1174.6 ± 793.5)mm3和(0.572 ± 0...
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Format: | Article |
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Language: | zho |
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Editorial Office of Journal of Sun Yat-sen University
2013-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
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Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43574464/ |
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