Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

Anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins are frequently overexpressed in various cancers, playing a pivotal role in cancer initiation and progression, as well as intrinsic or acquired resistance to therapy. Although inhibitors targeting BCL-2, such as Venetoclax, have shown efficacy...

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Bibliographic Details
Main Authors: Dongyue Jiao, Kun Chang, Jiamin Jin, Yingji Chen, Mo Ren, Yucong Zhang, Kun Gao, Yaoting Xu, Lixin Wang, Chenji Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
drug resistance
apoptosis
WSB2
ubiquitination
Venetoclax
Online Access:https://elifesciences.org/articles/98372
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