Quercetin inhibits cardiomyocyte apoptosis via Sirt3/SOD2/mitochondrial reactive oxygen species during myocardial ischemia–reperfusion injury

Quercetin inhibits cardiomyocyte apoptosis via Sirt3/SOD2/mitochondrial reactive oxygen species during myocardial ischemia–reperfusion injury

Background: Myocardial ischemia/reperfusion injury (MI/RI) can lead to impaired cardiac function. Quercetin (Que) has a positive effect and improves MI/RI. Sirtuin-3 (Sirt3) is a deacetylase that ameliorates oxidative stress and is associated with MI/RI. This study aimed to investigate the molecular...

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Bibliographic Details
Main Authors: Da Xiong, Xin Wang, Haiyu Wang, Xia Chen, Hongrong Li, Yongwu Li, Minghua Zhong, Jingcheng Gao, Zicong Zhao, Wenjun Ren
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Myocardial ischemia/reperfusion injury
Quercetin
Sirt3
SOD2
Mitochondrial ROS
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024150621
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