Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis

Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis

Abstract To investigate the treatment of ulcerative colitis by thymoquinone (TQ) through the Hedgehog signaling pathway and the composition of intestinal microbiota. A total of 24 male Balb/C mice were randomly divided into blank group, model group, thymoquinone low-dose group (20 mg/kg) and thymoqu...

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Bibliographic Details
Main Authors: Xixiang Huang, Tong Sun, Linxia Xu, Wei Liu, Zhi Ren, Zhenzeng Ma, Hailun Zheng, Dapeng Li, Qiangwu Wang, Xiquan Ke
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Thymoquinone
Ulcerative colitis
Dextran sulfate
Hedgehog signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-10892-4
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https://doi.org/10.1038/s41598-025-10892-4

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