Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Abstract Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects represents a critical breakthrough for managing gout progression. Natural products with polypharmacological properties offer promising leads for drug discovery. In this study, β-carboli...

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Main Authors: Zhijiao Zhang, Xiaoyu Shi, Ting Wu, Zhuhan He, Ruipeng Liang, Wenjie Ye, Zhenkun Wu, Hui Liao, Fengxin Zheng, Qian Yang, Zean Zhao, Yongjun Chen, Zhen Gao, Shuo Wang, Mei Wang, Zhenqian Wang, Danhui Qi, Mingyu Yang, Shujing Xu, Youzhao Wang, Tong Zhao, Javier Egea, Xinyong Liu, Jianxin Pang, Fan Yi, Peng Zhan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62645-6
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