Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Abstract Loss of synaptic activity correlates best with cognitive dysfunction in Alzheimer’s disease (AD). We have previously shown that mild inhibition of mitochondrial complex I with the small molecule tricyclic pyrone compound CP2 restores long-term potentiation and cognitive function assessed by...

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Bibliographic Details
Main Authors: Noah Keller, Trace A. Christensen, Erik J. Wanberg, Jeffrey L. Salisbury, Eugenia Trushina
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Serial block-face scanning electron microscopy (SBFSEM)
Three-dimensional electron microscopy (3D EM) reconstruction
Volume electron microscopy
Mitochondrial complex I inhibition
Synapse
Online Access:https://doi.org/10.1038/s41598-025-90925-0
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https://doi.org/10.1038/s41598-025-90925-0

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