Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALLResearch in context

Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALLResearch in context

Summary: Background: Chimeric antigen receptor (CAR) T-cells targeting CD19 have shown impressive outcomes in refractory/relapsed B-cell acute lymphoblastic leukaemia (r/r B-ALL); however, frequent relapse demands multi-targeted approaches. Methods: We report Spanish clinical data on the safety and...

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Main Authors: Berta González-Martínez, Víctor Galán-Gómez, Alfonso Navarro-Zapata, Isabel Mirones-Aguilar, Marta Cobo, Alicia Pernas-Sánchez, Susana Vallejo, Elena Sánchez-Zapardiel, Odelaisy León-Triana, Carlos Echecopar, Isabel Martínez-Romera, Pilar Guerra-García, Sonsoles San Román-Pacheco, Adela Escudero, Elisa Izquierdo, Manuel Izquierdo, Sara Naharro, Alicia Martín-Ayuso, Halin Bareke, Andrés París-Muñoz, Peirong Hu, Dina Schneider, Rimas J. Orentas, Jordi Minguillón, Antonio Pérez-Martínez
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Multitarget CAR-T therapy
Tandem CD19/CD22 CAR-T
Paediatric B-Cell precursor acute lymphoblastic leukaemia
Translational research
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425003160
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