NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway

NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway

Abstract SIRT3 knockout mice develop cardiac insufficiency due to decreased mitochondrial function. However, upregulation of the NAD+/NADH ratio can compensate for SIRT3 deficiency through the SIRT1/PGC-1α pathway, thereby improving mitochondrial function. We therefore hypothesized that upregulation...

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Bibliographic Details
Main Authors: Xiyao Zhao, Mengrui He, Lina He, Ruijie Han, Yanan Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
NMN
sirt3 knockdown
Mitochondria
PGC-1α
Online Access:https://doi.org/10.1038/s41598-025-14349-6
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https://doi.org/10.1038/s41598-025-14349-6

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