The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes

The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated stress response (ISR), a cellular pathway activated...

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Main Authors: Jiayi E. Wang, Charanya Muralidharan, Armando A. Puente, Titli Nargis, Jacob R. Enriquez, Ryan M. Anderson, Raghavendra G. Mirmira, Sarah A. Tersey
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
Unfolded protein response (UPR)
Inflammation
Macrophages
Diabetes
Pancreatic islet
Migration
Online Access:https://doi.org/10.1186/s12964-025-02372-z
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https://doi.org/10.1186/s12964-025-02372-z

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