Zbtb7b defines a compensatory mechanism in MASLD‐related HCC progression by suppressing H19‐mediated hepatic lipid deposition

Zbtb7b defines a compensatory mechanism in MASLD‐related HCC progression by suppressing H19‐mediated hepatic lipid deposition

Abstract Hepatocellular carcinoma (HCC) is a widely prevalent type of primary liver cancer. However, strategies for pretumor intervention are still limited. In this study, a liver‐specific Zbtb7b knockout mouse model was used to evaluate the role of Zbtb7b in metabolic dysfunction‐associated steatot...

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Bibliographic Details
Main Authors: Yinglin Han, Kaimin Wu, Xin Peng, Yinkun Fu, Wenyan Li, Jing Ma, He Jiang, Xu‐Yun Zhao
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Physiological Reports
Subjects:
de novo lipogenesis
fatty acid oxidation
H19
hepatocellular carcinoma
metabolic dysfunction‐associated steatotic liver disease
Zbtb7b
Online Access:https://doi.org/10.14814/phy2.70160
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https://doi.org/10.14814/phy2.70160

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