Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo

Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo

Abstract Background Neuropilin-1 (NRP1) is a transmembrane protein involved in surface receptor complexes for a variety of extracellular signals. NRP1 expression in human cancers is associated with prominent angiogenesis and advanced progression stage. However, the molecular mechanisms underlying NR...

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Main Authors: Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Endothelial cells
Exosomes
Neuropilin
miRNA
Ephrin-A3
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12964-025-02061-x
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