The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses
Abstract Adverse early-life experiences alter the regulation of major stress systems such as the hypothalamic-pituitary-adrenal (HPA) axis. Low early-life maternal care (MC) has repeatedly been related to blunted cortisol stress responses. Likewise, an acutely increased awareness of mortality (morta...
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2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85380-w |
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| author | Ulrike U. Bentele Paula Strobel Maria Meier Annika B. E. Benz Raphaela J. Gaertner Elea S. C. Klink Bernadette F. Denk Stephanie J. Dimitroff Eva Unternaehrer Jens C. Pruessner |
| author_facet | Ulrike U. Bentele Paula Strobel Maria Meier Annika B. E. Benz Raphaela J. Gaertner Elea S. C. Klink Bernadette F. Denk Stephanie J. Dimitroff Eva Unternaehrer Jens C. Pruessner |
| author_sort | Ulrike U. Bentele |
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| description | Abstract Adverse early-life experiences alter the regulation of major stress systems such as the hypothalamic-pituitary-adrenal (HPA) axis. Low early-life maternal care (MC) has repeatedly been related to blunted cortisol stress responses. Likewise, an acutely increased awareness of mortality (mortality salience [MS]) also has been shown to blunt cortisol responses. In this study we investigated the effects of early-life MC and a potential interaction with MS on HPA axis responsivity, as well as autonomic and subjective stress responses. Seventy-three women (M age =21.56, SD age =2.85) with self-reported low (n = 30) or high (n = 43) early-life MC, underwent the Trier Social Stress Test for groups. Before, they were asked to briefly contemplate either death (mortality condition, n = 38) or sleep (control condition, n = 35). Salivary cortisol and alpha amylase, heart rate variability and subjective stress levels were assessed repeatedly. Multilevel mixed models confirmed an effect of MC on stress system regulation, indicated by blunted cortisol responses and overall reduced heart rate variability in low versus high MC individuals. Moreover, we found an interaction between MS and MC concerning subjective stress and autonomic measures. Specifically, low MC individuals in the control compared to the mortality condition showed both overall higher subjective stress levels, and less increase in heart rate variability following stress. These findings demonstrate the enduring impact of low early-life MC and the potential role of acute mortality primes on the regulation of stress systems in healthy women. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-9cf43422d5e54355bdcb25e424229d142025-01-12T12:14:26ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-85380-wThe effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responsesUlrike U. Bentele0Paula Strobel1Maria Meier2Annika B. E. Benz3Raphaela J. Gaertner4Elea S. C. Klink5Bernadette F. Denk6Stephanie J. Dimitroff7Eva Unternaehrer8Jens C. Pruessner9Department of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, University of MontanaDepartment of Psychology, Division of Neuropsychology, University of ConstanceDepartment of Psychology, Division of Neuropsychology, University of ConstanceAbstract Adverse early-life experiences alter the regulation of major stress systems such as the hypothalamic-pituitary-adrenal (HPA) axis. Low early-life maternal care (MC) has repeatedly been related to blunted cortisol stress responses. Likewise, an acutely increased awareness of mortality (mortality salience [MS]) also has been shown to blunt cortisol responses. In this study we investigated the effects of early-life MC and a potential interaction with MS on HPA axis responsivity, as well as autonomic and subjective stress responses. Seventy-three women (M age =21.56, SD age =2.85) with self-reported low (n = 30) or high (n = 43) early-life MC, underwent the Trier Social Stress Test for groups. Before, they were asked to briefly contemplate either death (mortality condition, n = 38) or sleep (control condition, n = 35). Salivary cortisol and alpha amylase, heart rate variability and subjective stress levels were assessed repeatedly. Multilevel mixed models confirmed an effect of MC on stress system regulation, indicated by blunted cortisol responses and overall reduced heart rate variability in low versus high MC individuals. Moreover, we found an interaction between MS and MC concerning subjective stress and autonomic measures. Specifically, low MC individuals in the control compared to the mortality condition showed both overall higher subjective stress levels, and less increase in heart rate variability following stress. These findings demonstrate the enduring impact of low early-life MC and the potential role of acute mortality primes on the regulation of stress systems in healthy women.https://doi.org/10.1038/s41598-025-85380-wEarly-life adversityMaternal careMortality salienceHPA axisStressTSST |
| spellingShingle | Ulrike U. Bentele Paula Strobel Maria Meier Annika B. E. Benz Raphaela J. Gaertner Elea S. C. Klink Bernadette F. Denk Stephanie J. Dimitroff Eva Unternaehrer Jens C. Pruessner The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses Scientific Reports Early-life adversity Maternal care Mortality salience HPA axis Stress TSST |
| title | The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses |
| title_full | The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses |
| title_fullStr | The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses |
| title_full_unstemmed | The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses |
| title_short | The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses |
| title_sort | effect of mortality salience and early life maternal care on neuroendocrine autonomic and psychological stress responses |
| topic | Early-life adversity Maternal care Mortality salience HPA axis Stress TSST |
| url | https://doi.org/10.1038/s41598-025-85380-w |
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