Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival

Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival

Head and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response and prognosis. The tumor microenvironment (TME), which includes microbiome and immune cells, can impact outcomes. Here, we sought to relate the presence of specific microbes, gene expre...

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Main Authors: Rituraj Upadhyay, Aastha Dhakal, Caroline Wheeler, Rebecca Hoyd, Malvenderjit Jagjit Singh, Vidhya Karivedu, Priyanka Bhateja, Marcelo Bonomi, Sasha Valentin, Mauricio E. Gamez, David J. Konieczkowski, Sujith Baliga, John C. Grecula, Dukagjin M. Blakaj, Emile Gogineni, Darrion L. Mitchell, Nicholas C. Denko, Daniel Spakowicz, Sachin R. Jhawar
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Cancer Biology & Therapy
Subjects:
Tumor microbiome
molecular profiles
immune cell abundances
HPV
HNSCC
microbiome
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2024.2350249
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https://www.tandfonline.com/doi/10.1080/15384047.2024.2350249

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