Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis
Fetal goiter is a rare disorder not expected to be found during a healthy woman’s pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks’ g...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/9564737 |
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| author | Catarina Matos Figueiredo Inês Falcão Joana Vilaverde Joana Freitas Maria João Oliveira Cristina Godinho Jorge Dores Maria Céu Rodrigues Carmen Carvalho Teresa Borges |
| author_facet | Catarina Matos Figueiredo Inês Falcão Joana Vilaverde Joana Freitas Maria João Oliveira Cristina Godinho Jorge Dores Maria Céu Rodrigues Carmen Carvalho Teresa Borges |
| author_sort | Catarina Matos Figueiredo |
| collection | DOAJ |
| description | Fetal goiter is a rare disorder not expected to be found during a healthy woman’s pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks’ gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without polyhydramnios. Maternal thyroid function was normal and thyroid antibodies were negative. Two intra-amniotic levothyroxine infusions were performed at 32 and 33 weeks. Serial imaging control showed no progression of the mass. Elective caesarean section was performed at 38 weeks. The male newborn was admitted to the intensive care unit due to cardiorespiratory insufficiency with pulmonary hypertension. Hormonal assays revealed primary congenital hypothyroidism and ultrasonography confirmed diffuse goiter. Levothyroxine was started. Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene. |
| format | Article |
| id | doaj-art-9cb33c6de6af49679b7a9ac2c1d2ef55 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-9cb33c6de6af49679b7a9ac2c1d2ef552025-02-03T05:53:23ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/95647379564737Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to DyshormonogenesisCatarina Matos Figueiredo0Inês Falcão1Joana Vilaverde2Joana Freitas3Maria João Oliveira4Cristina Godinho5Jorge Dores6Maria Céu Rodrigues7Carmen Carvalho8Teresa Borges9Pediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalPediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalEndocrinology, Diabetes and Metabolism Department, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalPediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalPediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalNeonatal Intensive Care Unit, Neonatology and Pediatric Intensive Care Department, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalEndocrinology, Diabetes and Metabolism Department, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalPrenatal Diagnosis Unit, Obstetric Department, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalNeonatal Intensive Care Unit, Neonatology and Pediatric Intensive Care Department, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalPediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte–Centro Hospitalar Universitário do Porto, Oporto, PortugalFetal goiter is a rare disorder not expected to be found during a healthy woman’s pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks’ gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without polyhydramnios. Maternal thyroid function was normal and thyroid antibodies were negative. Two intra-amniotic levothyroxine infusions were performed at 32 and 33 weeks. Serial imaging control showed no progression of the mass. Elective caesarean section was performed at 38 weeks. The male newborn was admitted to the intensive care unit due to cardiorespiratory insufficiency with pulmonary hypertension. Hormonal assays revealed primary congenital hypothyroidism and ultrasonography confirmed diffuse goiter. Levothyroxine was started. Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene.http://dx.doi.org/10.1155/2018/9564737 |
| spellingShingle | Catarina Matos Figueiredo Inês Falcão Joana Vilaverde Joana Freitas Maria João Oliveira Cristina Godinho Jorge Dores Maria Céu Rodrigues Carmen Carvalho Teresa Borges Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis Case Reports in Endocrinology |
| title | Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis |
| title_full | Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis |
| title_fullStr | Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis |
| title_full_unstemmed | Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis |
| title_short | Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis |
| title_sort | prenatal diagnosis and management of a fetal goiter hypothyroidism due to dyshormonogenesis |
| url | http://dx.doi.org/10.1155/2018/9564737 |
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