Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial

Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial

Introduction Septic shock is a common and highly morbid condition. To date, there is no specific therapy proven to attenuate organ injury in septic shock. Recent studies have suggested a role for the combination of ascorbic acid, corticosteroids and thiamine, although randomised data are lacking.Met...

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Main Authors: Ronny Otero, Ari Moskowitz, Tuyen Yankama, Lars W Andersen, David T Huang, Michael W Donnino, Anne V Grossestreuer, Lance B Becker, Katherine M Berg, Maureen Chase, Michael N Cocchi, Pratik Doshi, Jonathan Gong, Anne Grossestreuer, Mark Hershey, Ayelet Hilewitz, Peter C Hou, Hyung K Kim, Maksim Korotun, Jessica B McCannon, Paul E Marik, Ayan Sen, Robert L Sherwin, Junior Uduman
Format: Article
Language:English
Published: BMJ Publishing Group 2019-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/9/12/e034406.full
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https://bmjopen.bmj.com/content/9/12/e034406.full

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