CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms

CYP3A, a key member of the cytochrome P450 (CYP450) superfamily, is integral to drug metabolism, processing a substantial portion of medications. Their role in drug metabolism is particularly prominent, as CYP3A4 and CYP3A5 metabolize approximately 30–50% of known drugs. The genetic polymorphism of...

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Bibliographic Details
Main Authors: Yuqing Zhang, Ziying Wang, Yuchao Wang, Weikai Jin, Zheyan Zhang, Lehao Jin, Jianchang Qian, Long Zheng
Format: Article
Language:English
Published: PeerJ Inc. 2024-12-01
Series:PeerJ
Subjects:
CYP3A4
CYP3A5
Genetic polymorphism
Drug interactions
Inter-individual variability
Enzyme kinetics
Online Access:https://peerj.com/articles/18636.pdf
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