Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation

Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation

Podocyte injury is a critical event in the pathogenesis of diabetic nephropathy (DN). Hyperglycemia, oxidative stress, inflammation, and other factors contribute to podocyte damage in DN. In this study, we demonstrate that signaling regulatory protein alpha (SIRPα) plays a pivotal role in regulating...

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Bibliographic Details
Main Authors: Yang Chen, Mingchao Zhang, Ruoyu Jia, Bin Qian, Chenyang Jing, Caihong Zeng, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Redox Biology
Subjects:
SIRPα
Podocyte injury
PKM2
Oxidative stress
Aerobic glycolysis
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004178
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