Association of psychosocial factors and biological pathways identified from rare-variant analysis with longitudinal trajectories of treatment response in major depressive disorder

Association of psychosocial factors and biological pathways identified from rare-variant analysis with longitudinal trajectories of treatment response in major depressive disorder

Abstract Background Antidepressant efficacy is influenced by a multitude of factors, yet predicting treatment outcomes remains challenging. This difficulty is partly due to the commonly employed dichotomous classifications of treatment response that rely on a single primary endpoint. Methods The stu...

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Main Authors: Haiping Tang, Yan Xia, Chenjie Gao, Yufan Cai, Yongqi Shao, Wenji Chen, Yonggui Yuan, Chunyu Liu, Zhijun Zhang, Zhi Xu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Psychiatry
Subjects:
Antidepressant efficacy
Target exome sequencing
Rare variants
Response trajectories
Genetic factors
Psychosocial factors
Online Access:https://doi.org/10.1186/s12888-025-06895-0
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https://doi.org/10.1186/s12888-025-06895-0

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