Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation

Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation

Abstract Background Liver fibrosis is a progressive pathological process primarily driven by the transdifferentiation of hepatic stellate cells (HSCs) into myofibroblast-like cells which secrete excessive extracellular matrix (ECM). Although microRNAs (miRNAs) have emerged as key regulators of fibro...

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Bibliographic Details
Main Authors: Fangqing Zhao, Xuan Niu, Ge Song, Lijie Wang, Yisheng Fu, Shuwen Li, Xinxin Gu, Qingkun Wang, Jiao Luo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
AAV
MiR-214
Hepatic stellate cell
Liver fibrosis
Gene therapy
Online Access:https://doi.org/10.1186/s12967-025-06880-x
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https://doi.org/10.1186/s12967-025-06880-x

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