KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.

KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.

Molecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we identify Mamu-A1*00201 (Mamu-A*02), a common MHC class I molecule in the rhesus...

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Main Authors: Arnaud D Colantonio, Benjamin N Bimber, William J Neidermyer, R Keith Reeves, Galit Alter, Marcus Altfeld, R Paul Johnson, Mary Carrington, David H O'Connor, David T Evans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001316&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001316&type=printable

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