Dynamic strain and β-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells

Dynamic strain and β-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells

Multipotent bone marrow mesenchymal stromal/stem cells (MSCs) respond to mechanical forces. MSCs perceive static and dynamic forces through focal adhesions, as well as cytoskeletal and intranuclear actin. Dynamic strain stimulates nuclear β-catenin (Ctnnb1) that controls gene expression and suppress...

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Bibliographic Details
Main Authors: Parisa Dashti, Eric A. Lewallen, Gary S. Stein, Bram C.J. van der Eerden, Johannes P.T.M. van Leeuwen, Andre J. van Wijnen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Dynamic strain
Mesenchymal stem cell
Osteoblast
Bone
Chromatin
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824002115
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http://www.sciencedirect.com/science/article/pii/S2405580824002115

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