Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis

Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis

Abstract Introduction Non-alcoholic fatty liver disease (NAFLD) represents the most widespread liver disease globally, ranging from non-alcoholic fatty liver (NAFL) and steatohepatitis (NASH) to fibrosis/cirrhosis, with potential progression to hepatocellular carcinoma (HCC). Genome-wide association...

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Main Authors: Ruofan Li, Kaiyan Su, Tianzhun Wu, Li Xu, Wenyu Song, Dandan Sun, Tao Zeng, Jinzhang Chen, Haibei Xin, Yuanfeng Li, Mengya Zang, Minggen Hu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Non-alcoholic fatty liver disease
Genome-wide association study
Single nucleotide polymorphism
GGT1
Online Access:https://doi.org/10.1186/s12864-025-11668-w
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