Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report
Guillain-Barré Syndrome (GBS) following tetanus immunisation during pregnancy is an extremely rare occurrence. GBS is an autoimmune disorder in which the immune system targets peripheral nerves, causing muscle weakness and in extreme cases, paralysis. GBS after vaccination, especially after the teta...
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JCDR Research and Publications Private Limited
2025-01-01
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| Online Access: | https://jcdr.net/articles/PDF/20489/75651_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_IS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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| author | Jagannath Dhadwad Prince Yadav Kunal Modi Bana Reddy Chandan Kumar Dash |
| author_facet | Jagannath Dhadwad Prince Yadav Kunal Modi Bana Reddy Chandan Kumar Dash |
| author_sort | Jagannath Dhadwad |
| collection | DOAJ |
| description | Guillain-Barré Syndrome (GBS) following tetanus immunisation during pregnancy is an extremely rare occurrence. GBS is an autoimmune disorder in which the immune system targets peripheral nerves, causing muscle weakness and in extreme cases, paralysis. GBS after vaccination, especially after the tetanus, diphtheria and pertussis (Tdap) vaccine, is extremely rare. Here, a case of 21-year-old woman (G2A1, gravida 2, abortion 1) with acute onset of bilateral symmetrical ascending paralysis with areflexia in both upper and lower limbs, with a prior history of Tetanus vaccination 15 days back is described. The patient was examined thoroughly and all other causes were ruled out. Management of this patient was challenging, as it required treating the GBS along with ensuring the wellbeing of the foetus. The aetiological diagnosis also posed a challenge, as there was no clear history of any incriminating cause. Intravenous Immunoglobulins (IVIG) and physiotherapy were given which led to an improvement in the patient's condition. Although the routine practices followed in pregnancy, like vaccination, is vital, this case highlights the potential complications of the same. Reporting such cases is essential to enhance understanding of vaccine safety and guide future recommendations. The clinical implications enforce the need for early diagnosis and prompt management to ensure favourable outcomes for both the mother and foetus. |
| format | Article |
| id | doaj-art-9b2d7e11b517419e919417e5bb4d7bc1 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-9b2d7e11b517419e919417e5bb4d7bc12025-01-16T12:24:24ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901131810.7860/JCDR/2025/75651.20489Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case ReportJagannath Dhadwad0 Prince Yadav1Kunal Modi2Bana Reddy3Chandan Kumar Dash4Professor, Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.Junior Resident, Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.Junior Resident, Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.Assistant Professor, Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.Junior Resident, Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.Guillain-Barré Syndrome (GBS) following tetanus immunisation during pregnancy is an extremely rare occurrence. GBS is an autoimmune disorder in which the immune system targets peripheral nerves, causing muscle weakness and in extreme cases, paralysis. GBS after vaccination, especially after the tetanus, diphtheria and pertussis (Tdap) vaccine, is extremely rare. Here, a case of 21-year-old woman (G2A1, gravida 2, abortion 1) with acute onset of bilateral symmetrical ascending paralysis with areflexia in both upper and lower limbs, with a prior history of Tetanus vaccination 15 days back is described. The patient was examined thoroughly and all other causes were ruled out. Management of this patient was challenging, as it required treating the GBS along with ensuring the wellbeing of the foetus. The aetiological diagnosis also posed a challenge, as there was no clear history of any incriminating cause. Intravenous Immunoglobulins (IVIG) and physiotherapy were given which led to an improvement in the patient's condition. Although the routine practices followed in pregnancy, like vaccination, is vital, this case highlights the potential complications of the same. Reporting such cases is essential to enhance understanding of vaccine safety and guide future recommendations. The clinical implications enforce the need for early diagnosis and prompt management to ensure favourable outcomes for both the mother and foetus.https://jcdr.net/articles/PDF/20489/75651_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_IS)_PFA(IS)_PB(AG_IS)_PN(IS).pdfantenatal careautoimmune diseaseimmunisationintravenous immunoglobulinsphysiotherapy |
| spellingShingle | Jagannath Dhadwad Prince Yadav Kunal Modi Bana Reddy Chandan Kumar Dash Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report Journal of Clinical and Diagnostic Research antenatal care autoimmune disease immunisation intravenous immunoglobulins physiotherapy |
| title | Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report |
| title_full | Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report |
| title_fullStr | Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report |
| title_full_unstemmed | Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report |
| title_short | Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report |
| title_sort | guillain barre syndrome triggered by tetanus vaccination during pregnancy a rare case report |
| topic | antenatal care autoimmune disease immunisation intravenous immunoglobulins physiotherapy |
| url | https://jcdr.net/articles/PDF/20489/75651_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_IS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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