Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss

Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss

Abstract Prolonged exposure of mammalian cells to hypotonic environments stimulates the development of sometimes large and numerous vacuoles of unknown origin. Here, we investigate the nature and formation of these vacuoles, which we term LateVacs. Vacuolation starts after osmotic cell swelling has...

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Bibliographic Details
Main Authors: Emily Zook, Yingzhou Edward Pan, Anna Wipplinger, Hubert H. Kerschbaum, Robert J. Clements, Markus Ritter, Tobias Stauber, Michael A. Model
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Hypotonicity
Lysosome
Vacuole
WNK kinase
Online Access:https://doi.org/10.1038/s41598-024-79815-z
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