Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner

Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner

Abstract Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology. MPP+ accumulation in mitochondria, a key factor in MPTP-induced neurodegeneration, leads to mitochondrial dysfunct...

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Bibliographic Details
Main Authors: Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
MPP+
Mitochondria
Organic cation transporter 3
TIMM22
Neurodegeneration
Online Access:https://doi.org/10.1186/s12915-025-02318-4
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https://doi.org/10.1186/s12915-025-02318-4

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