Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling

Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling

Summary: The vagus nerve is proposed to enable communication between the gut microbiome and the brain, but activity-based evidence is lacking. We find that mice reared germ-free exhibit decreased vagal tone relative to colonized controls, which is reversed via microbiota restoration. Perfusing antib...

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Main Authors: Kelly G. Jameson, Sabeen A. Kazmi, Takahiro E. Ohara, Celine Son, Kristie B. Yu, Donya Mazdeyasnan, Emma Leshan, Helen E. Vuong, Jorge Paramo, Arlene Lopez-Romero, Long Yang, Felix E. Schweizer, Elaine Y. Hsiao
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Neuroscience
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029262
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http://www.sciencedirect.com/science/article/pii/S2589004224029262

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