High metastatic tumor-derived CXCL16 mediates liver colonization metastasis by inducing Kupffer cell polarization via the PI3K/AKT/FOXO3a pathway

High metastatic tumor-derived CXCL16 mediates liver colonization metastasis by inducing Kupffer cell polarization via the PI3K/AKT/FOXO3a pathway

Liver metastases represent a late-stage manifestation of numerous cancers, often associated with poor patient prognosis. Kupffer cells (KCs), resident liver macrophages, play a critical role in liver metastasis (LM). However, the mechanisms by which the polarization of KCs facilitate colorectal canc...

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Main Authors: Yin Liu, Yunpeng Zhai, Yi Zhang, Liming Song, Hanyue Zhang, Jiahui Cao, Senfeng Zhao, Yahui Wu, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Yuling Sun
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Kupffer cells
Liver metastasis
Colorectal cancer
CXCL16
CD206
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000533
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