Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota

Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota

ABSTRACT The amyloid deposition-to-cognitive impairment pathway is crucial in Alzheimer’s disease (AD) pathogenesis, with gut microbes influencing its development. Our study evaluated Clostridium butyricum MIYAIRI 588 (CBM588) as a potential AD treatment. In APP/PS1 mice, CBM588 improved cognitive f...

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Main Authors: Ye Shiqing, Lu Xinjie, Zhu Xiaotong, Chen Jiayan, Lu Jiahai, Chen Xiaodong, Lou Yongliang, Li Xiang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Alzheimer’s disease
Clostridium butyricum
intestinal microbiota
short-chain fatty acid
neuroinflammation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00178-25
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https://journals.asm.org/doi/10.1128/spectrum.00178-25

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