Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Abstract The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affe...

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Bibliographic Details
Main Authors: William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger
Format: Article
Language:English
Published: Springer Nature 2009-01-01
Series:Molecular Systems Biology
Subjects:
EGFR
ErbB
ODE model
parameter optimization
signal transduction
Online Access:https://doi.org/10.1038/msb.2008.74
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https://doi.org/10.1038/msb.2008.74

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