GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation

GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation

Abstract Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) is an important cause of neurological impairment and leads to considerable morbidity and mortality. The stability of the blood-brain barrier (BBB) is crucial for minimizing secondary neurological damage and improving long-term pr...

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Bibliographic Details
Main Authors: Pengyu Duan, Xiaoyan Li, Yonghong Bi, Weiyu Feng, Zhehao Jin, Xiaoqian Zhang, Guanghui He, Da An, Zhibin Wen, Bing Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Autophagy mediated degradation
Blood-brain barrier
Cardiac arrest and resuscitation
GYY4137
Occludin
Online Access:https://doi.org/10.1038/s41598-024-84948-2
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