Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine
Liquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. The rapid assessment of liquid biopsy techniques facilitates early cancer diagnosis and prognosis. Early and precise detection of tumor biomarkers provides...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/1424-8220/24/24/7902 |
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| author | Panagiota M. Kalligosfyri Eleni Lamprou Despina P. Kalogianni |
| author_facet | Panagiota M. Kalligosfyri Eleni Lamprou Despina P. Kalogianni |
| author_sort | Panagiota M. Kalligosfyri |
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| description | Liquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. The rapid assessment of liquid biopsy techniques facilitates early cancer diagnosis and prognosis. Early and precise detection of tumor biomarkers provides crucial information about the tumor that guides clinicians towards effective personalized medicine. Point-of-care-testing remains still a great challenge in cancer diagnostics. Liquid biopsy is a promising alternative to tissue biopsy with the great advantages of less invasion and real-time monitoring of the disease, also providing information about tumor heterogeneity. The field is continuously and rapidly expanding. Numerous sophisticated biosensors have been developed targeting several biomarkers to achieve low detection limits, increased specificity and robustness. Current biosensors include mainly optical sensors, such as colorimetric, fluorescent, SPR, SERS and lateral flow assays. Electrochemical sensors have also been developed, providing very low detection limits. Colorimetric sensors exhibited simplicity in signal interpretation, while fluorescent sensors contributed to low analysis times, and SPR/SERS enabled label-free and rapid analysis. Novel target amplification and signal enhancement techniques have been exploited to increase the detectability of the sensors. In this context, this review is focused on the recent advances in biosensing technology for cutting-edge liquid biopsy applications towards point-of-care testing. |
| format | Article |
| id | doaj-art-9988ffbd7ec14f9782f8ed37b6dc7eaa |
| institution | Kabale University |
| issn | 1424-8220 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-9988ffbd7ec14f9782f8ed37b6dc7eaa2024-12-27T14:52:23ZengMDPI AGSensors1424-82202024-12-012424790210.3390/s24247902Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized MedicinePanagiota M. Kalligosfyri0Eleni Lamprou1Despina P. Kalogianni2Department of Chemistry, University of Patras, GR26504 Patras, GreeceDepartment of Chemistry, University of Patras, GR26504 Patras, GreeceDepartment of Chemistry, University of Patras, GR26504 Patras, GreeceLiquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. The rapid assessment of liquid biopsy techniques facilitates early cancer diagnosis and prognosis. Early and precise detection of tumor biomarkers provides crucial information about the tumor that guides clinicians towards effective personalized medicine. Point-of-care-testing remains still a great challenge in cancer diagnostics. Liquid biopsy is a promising alternative to tissue biopsy with the great advantages of less invasion and real-time monitoring of the disease, also providing information about tumor heterogeneity. The field is continuously and rapidly expanding. Numerous sophisticated biosensors have been developed targeting several biomarkers to achieve low detection limits, increased specificity and robustness. Current biosensors include mainly optical sensors, such as colorimetric, fluorescent, SPR, SERS and lateral flow assays. Electrochemical sensors have also been developed, providing very low detection limits. Colorimetric sensors exhibited simplicity in signal interpretation, while fluorescent sensors contributed to low analysis times, and SPR/SERS enabled label-free and rapid analysis. Novel target amplification and signal enhancement techniques have been exploited to increase the detectability of the sensors. In this context, this review is focused on the recent advances in biosensing technology for cutting-edge liquid biopsy applications towards point-of-care testing.https://www.mdpi.com/1424-8220/24/24/7902microRNAcirculating tumor DNAcirculating tumor cellsexosomesoptical sensorslateral flow assay |
| spellingShingle | Panagiota M. Kalligosfyri Eleni Lamprou Despina P. Kalogianni Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine Sensors microRNA circulating tumor DNA circulating tumor cells exosomes optical sensors lateral flow assay |
| title | Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine |
| title_full | Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine |
| title_fullStr | Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine |
| title_full_unstemmed | Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine |
| title_short | Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine |
| title_sort | emerging sensing technologies for liquid biopsy applications steps closer to personalized medicine |
| topic | microRNA circulating tumor DNA circulating tumor cells exosomes optical sensors lateral flow assay |
| url | https://www.mdpi.com/1424-8220/24/24/7902 |
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