Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway

Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway

Abstract Background Epalrestat (EPS), an aldose reductase inhibitor, is used to alleviate peripheral nerve disorder of diabetic patients in clinical therapy. Even though EPS exerted effects in central nervous system diseases, the neuroprotection and underlying molecular mechanism in neurodegenerativ...

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Bibliographic Details
Main Authors: Huafang Jia, Mengru Liu, Hong Jiang, Zhen Qiao, Kaiyue Ren, Xixun Du, Xi Chen, Qian Jiao, Fengyuan Che
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Epalrestat
Parkinson’s disease
KEAP1
Nrf2
Oxidative stress
Mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s12974-025-03455-x
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https://doi.org/10.1186/s12974-025-03455-x

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