Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report
Xiaoyan Lu,* Hangfei Wu,* Yuhao Tan, Xiaowei Mao Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaowei Mao, Departme...
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Dove Medical Press
2025-01-01
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| author | Lu X Wu H Tan Y Mao X |
| author_facet | Lu X Wu H Tan Y Mao X |
| author_sort | Lu X |
| collection | DOAJ |
| description | Xiaoyan Lu,* Hangfei Wu,* Yuhao Tan, Xiaowei Mao Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaowei Mao, Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China, Email xiaoweimaoamtf@163.comBackground: Coexistence of autoimmune encephalitis (AE) with multiple autoantibodies is of particular concern because overlying antibodies may cause variation of clinical manifestations. Coexistence of anti-glutamic acid decarboxylase (GAD) and anti-Gamma-aminobutyric acid-α-receptor (GABAAR) antibodies in AE was rare.Case Presentation: A 44-year-old female patient presented to our hospital due to cognitive decline for 4 years, seizures, slowed speech and depression for 2 months. Based on her clinical manifestations and laboratory assessment results (positive anti-GAD and anti-GABAAR antibodies), she was diagnosed as AE with coexisting anti-GAD and anti-GABAAR antibodies. After treatment with intravenous methylprednisolone (at dose of 1000mg/d, 500mg/d, 250mg/d, 120mg/d, 80mg/d for 3 days respectively) and intravenous immunoglobulin (400 mg/kg/d for 5 days), her symptoms gradually improved with exception for the slowed speech. Oral prednisone acetate was continued after discharge, her symptoms of slowed speech improved at 6-month follow-up.Conclusion: We report a case of AE co-existing with anti-GAD and anti-GABAAR antibodies, which has different characteristics from previous cases. Coexistence of neural auto-antibodies should be considered when patients suspected with autoimmune encephalitis.Keywords: autoimmune encephalitis, anti-GAD antibody, anti-GABAAR antibody |
| format | Article |
| id | doaj-art-990a240617f1417a9344769cd5f93681 |
| institution | Kabale University |
| issn | 1179-142X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj-art-990a240617f1417a9344769cd5f936812025-01-16T16:17:13ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2025-01-01Volume 1810510999305Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case ReportLu XWu HTan YMao XXiaoyan Lu,* Hangfei Wu,* Yuhao Tan, Xiaowei Mao Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaowei Mao, Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China, Email xiaoweimaoamtf@163.comBackground: Coexistence of autoimmune encephalitis (AE) with multiple autoantibodies is of particular concern because overlying antibodies may cause variation of clinical manifestations. Coexistence of anti-glutamic acid decarboxylase (GAD) and anti-Gamma-aminobutyric acid-α-receptor (GABAAR) antibodies in AE was rare.Case Presentation: A 44-year-old female patient presented to our hospital due to cognitive decline for 4 years, seizures, slowed speech and depression for 2 months. Based on her clinical manifestations and laboratory assessment results (positive anti-GAD and anti-GABAAR antibodies), she was diagnosed as AE with coexisting anti-GAD and anti-GABAAR antibodies. After treatment with intravenous methylprednisolone (at dose of 1000mg/d, 500mg/d, 250mg/d, 120mg/d, 80mg/d for 3 days respectively) and intravenous immunoglobulin (400 mg/kg/d for 5 days), her symptoms gradually improved with exception for the slowed speech. Oral prednisone acetate was continued after discharge, her symptoms of slowed speech improved at 6-month follow-up.Conclusion: We report a case of AE co-existing with anti-GAD and anti-GABAAR antibodies, which has different characteristics from previous cases. Coexistence of neural auto-antibodies should be considered when patients suspected with autoimmune encephalitis.Keywords: autoimmune encephalitis, anti-GAD antibody, anti-GABAAR antibodyhttps://www.dovepress.com/coexistence-of-anti-gad-and-anti-gabaar-antibodies-in-an-autoimmune-en-peer-reviewed-fulltext-article-IMCRJautoimmune encephalitisanti-gad antibodyanti-gabaar antibody. |
| spellingShingle | Lu X Wu H Tan Y Mao X Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report International Medical Case Reports Journal autoimmune encephalitis anti-gad antibody anti-gabaar antibody. |
| title | Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report |
| title_full | Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report |
| title_fullStr | Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report |
| title_full_unstemmed | Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report |
| title_short | Coexistence of Anti-GAD and Anti-GABAAR Antibodies in an Autoimmune Encephalitis Patient: A Case Report |
| title_sort | coexistence of anti gad and anti gabaar antibodies in an autoimmune encephalitis patient a case report |
| topic | autoimmune encephalitis anti-gad antibody anti-gabaar antibody. |
| url | https://www.dovepress.com/coexistence-of-anti-gad-and-anti-gabaar-antibodies-in-an-autoimmune-en-peer-reviewed-fulltext-article-IMCRJ |
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