Neuraminidase-mediated enhancement of Streptococcus pneumoniae colonization is associated with altered mucus characteristics and distribution

Neuraminidase-mediated enhancement of Streptococcus pneumoniae colonization is associated with altered mucus characteristics and distribution

ABSTRACT Upon entry into the upper respiratory tract (URT), Streptococcus pneumoniae (Spn) upregulates neuraminidases (NA) that cleave sialic acid (SA) from host glycans. Because sialylation is thought to contribute to the physical properties that determine mucus function, we posited that Spn direct...

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Bibliographic Details
Main Authors: Matthew T. Montgomery, Mila Ortigoza, Cynthia Loomis, Jeffrey N. Weiser
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
Streptococcus pneumoniae
neuraminidase
upper respiratory tract
colonization
mucus
Online Access:https://journals.asm.org/doi/10.1128/mbio.02579-24
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