Exploring the therapeutic potential of Sirt6-enriched adipose stem cell-derived exosomes in myocardial ischemia–reperfusion injury: unfolding new epigenetic frontiers

Exploring the therapeutic potential of Sirt6-enriched adipose stem cell-derived exosomes in myocardial ischemia–reperfusion injury: unfolding new epigenetic frontiers

Abstract Background The management of myocardial ischemia–reperfusion injury (MIRI) presents continuous therapeutic challenges. NAD-dependent deacetylase Sirtuin 6 (Sirt6) plays distinct roles in various disease contexts and is hence investigated for potential therapeutic applications for MIRI. This...

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Bibliographic Details
Main Authors: Kun Liu, Hecheng Wang, Yiou Wang, Xiaoxu Zhang, Ruihu Wang, Zhaoxuan Zhang, Jian Wang, Xinran Lu, Xiaoyu Wu, Yanshuo Han
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Clinical Epigenetics
Subjects:
Sirtuin 6
Adipose stem cell-derived exosomes
Myocardial ischemia–reperfusion injury
Mitophagy
Pyroptosis
Anoxia-reoxygenation
Online Access:https://doi.org/10.1186/s13148-023-01618-2
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https://doi.org/10.1186/s13148-023-01618-2

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