Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands

Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands

The liver plays a central role in fat storage, but little is known about physiological fat accumulation during early development. Here we investigated a transient surge in hepatic lipid droplets observed in newborn mice immediately after birth. We developed a novel model to quantify liver fat conten...

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Main Authors: Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Lipid Research
Subjects:
liver
newborn
lipid droplets
milk
TLR4
palmitic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000045
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