A magnetic epitope-imprinted microsphere used for selective separation and rapid detection of SHV-type β-lactamases in bacteria: a novel strategy of antimicrobial resistance detection

A magnetic epitope-imprinted microsphere used for selective separation and rapid detection of SHV-type β-lactamases in bacteria: a novel strategy of antimicrobial resistance detection

Abstract Background The production of β-lactamases is the most prevalent resistance mechanism for β-lactam antibiotics in Gram-negative bacteria. Presently, over 4900 β-lactamases have been discovered, and they are categorized into hundreds of families. In each enzyme family, amino acid substitution...

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Main Authors: Yusun Zhou, Kunqi Wang, Lele Li, Hui Li, Qingwu Tian, Baosheng Ge, Yuanyuan Chi, Xiaotong Xu, Shuhui Liu, Meng Han, Tingting Zhou, Yuanqi Zhu, Qing Wang, Bing Yu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
Antimicrobial resistance detection
β-Lactamases
SHV family
Epitope imprinting
Protein-specific recognition
Online Access:https://doi.org/10.1186/s12951-024-02949-9
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https://doi.org/10.1186/s12951-024-02949-9

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