Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response

Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response

The gut microbiota influences the reactivity of the immune system, and Parabacteroides distasonis has emerged as an anti-inflammatory commensal. Here, we investigated whether its lysate could prevent severe forms of neuroinflammation in experimental autoimmune encephalomyelitis (EAE) in mice and how...

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Main Authors: Zuzana Jiraskova Zakostelska, Michal Kraus, Stepan Coufal, Petra Prochazkova, Zaneta Slavickova, Tomas Thon, Tomas Hrncir, Jakub Kreisinger, Klara Kostovcikova, Pavlina Kleinova, Jana Lizrova Preiningerova, Miluse Pavelcova, Veronika Ticha, Ivana Kovarova, Eva Kubala Havrdova, Helena Tlaskalova-Hogenova, Miloslav Kverka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
inflammation
Parabacteroides distasonis
microbiota
regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475126/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475126/full

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