A spectrum of nonsense-mediated mRNA decay efficiency along the degree of mutational constraint

Abstract Despite its importance for regulating gene expression, nonsense-mediated mRNA decay (NMD) remains poorly understood. Here, we extend the findings of a previous landmark study that proposed several factors associated with NMD efficiency using matched genome and transcriptome data from The Ca...

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Bibliographic Details
Main Authors: Young-gon Kim, Hyunju Kang, Beomki Lee, Hyeok-Jae Jang, Jong-ho Park, Changhee Ha, Hogun Park, Jong-Won Kim
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07136-y
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